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Patent Portfolio

50 USPTO provisional patent applications in computational drug repurposing, AI methodology, and novel inventions. The anchor program is in scleroderma and its CREST features, developed with LINCS signature-reversal analysis. The remaining disease-specific filings are earlier-stage candidate generation with secured priority dates.

50

Patents Filed

1

Most-Developed Anchor Program

2026

Priority Dates (Feb–Apr)

Anchor Program — Scleroderma / CREST Mechanisms

MEK inhibition

Two independent scaffolds converge in SSc fibroblasts

SRC / ABL

Recurs across the CREST cluster; SSc fibrosis rationale

PI3K-gamma

Consistent with SSc vasculopathy biology

Independent corroboration

Published preclinical work on the SRC/ABL axis reaches a convergent conclusion in SSc fibrosis (not a clinical claim)

These mechanisms are derived from the scleroderma/CREST signature-reversal analysis. The remaining indications below are earlier-stage filed candidates with secured priority dates, not validated leads.

Autoimmune & Inflammatory

18 patents

P01 · 63/990,695 · Feb 25, 2026

Scleroderma (SSc)

CREST anchor · LINCS signature-reversal

Spec Paper

P07 · 64/006,744 · Mar 16, 2026

Calcinosis

CREST anchor · LINCS signature-reversal

Spec Paper

P08 · 64/007,178 · Mar 16, 2026

Raynaud's Phenomenon

CREST anchor · LINCS signature-reversal

Spec Paper

P09 · 64/007,491 · Mar 16, 2026

Esophageal Dysmotility

CREST anchor · LINCS signature-reversal

Spec Paper

P10 · 64/008,496 · Mar 17, 2026

Telangiectasia

CREST anchor · LINCS signature-reversal

Spec Paper

P11 · 64/009,680 · Mar 18, 2026

Psoriasis

scRNA-seq · early-stage candidate

Spec Paper

P12 · 64/010,762 · Mar 19, 2026

IBD / Crohn's Disease

scRNA-seq · early-stage candidate

Spec Paper

P13 · 64/011,008 · Mar 19, 2026

irAE Inflammatory Arthritis

scRNA-seq · early-stage candidate

Spec Paper

P14 · 64/012,196 · Mar 20, 2026

Autoimmune Hemolytic Anemia

scRNA-seq · early-stage candidate

Spec Paper

P16 · 64/012,523 · Mar 21, 2026

Atopic Dermatitis

scRNA-seq · early-stage candidate

Spec Paper

P17 · 64/012,548 · Mar 21, 2026

Systemic Lupus Erythematosus

scRNA-seq · early-stage candidate

Spec Paper

P19 · 64/012,657 · Mar 21, 2026

Ulcerative Colitis

scRNA-seq · early-stage candidate

Spec Paper

P30 · 64/018,614 · Mar 27, 2026

Lupus Nephritis

scRNA-seq · early-stage candidate

Spec Paper

P38 · 64/020,925 · Mar 29, 2026

Rheumatoid Arthritis

scRNA-seq · early-stage candidate

Spec Paper

P39 · 64/021,948 · Mar 30, 2026

Sjogren's Syndrome

scRNA-seq · early-stage candidate

Spec Paper

P41 · 64/022,609 · Mar 31, 2026

Dermatomyositis

scRNA-seq · early-stage candidate

Spec Paper

P43 · 64/025,147 · Apr 1, 2026

Psoriatic Arthritis

scRNA-seq · early-stage candidate

Spec Paper

P44 · 64/025,679 · Apr 2, 2026

Ankylosing Spondylitis

scRNA-seq · early-stage candidate

Spec Paper

Neurodegenerative & Neurological

7 patents

P18 · 64/012,619 · Mar 21, 2026

Multiple Sclerosis (CSF)

scRNA-seq · early-stage candidate

Spec Paper

P20 · 64/012,709 · Mar 21, 2026

Ab-IDD / NMOSD (CSF)

scRNA-seq · early-stage candidate

Spec Paper

P22 · 64/013,194 · Mar 22, 2026

Migraine (Trigeminal Ganglion / CAMK2A)

scRNA-seq · early-stage candidate

Spec Paper

P25 · 64/014,341 · Mar 23, 2026

Alzheimer's Disease (SYK / Microglia)

scRNA-seq · early-stage candidate

Spec Paper

P26 · 64/015,045 · Mar 24, 2026

Parkinson's Disease

scRNA-seq · early-stage candidate

Spec Paper

P27 · 64/016,256 · Mar 25, 2026

ALS

scRNA-seq · early-stage candidate

Spec Paper

P28 · 64/016,898 · Mar 25, 2026

Huntington's Disease

scRNA-seq · early-stage candidate

Spec Paper

P29 · 64/017,924 · Mar 26, 2026

Frontotemporal Dementia

scRNA-seq · early-stage candidate

Spec Paper

Pulmonary & Respiratory

4 patents

P23 · 64/013,288 · Mar 22, 2026

eCRSwNP / Allergic Rhinitis

scRNA-seq · early-stage candidate

Spec Paper

P24 · 64/013,443 · Mar 22, 2026

Asthma (Bronchial)

scRNA-seq · early-stage candidate

Spec Paper

P34 · 64/020,036 · Mar 28, 2026

Idiopathic Pulmonary Fibrosis

scRNA-seq · early-stage candidate

Spec Paper

P35 · 64/020,546 · Mar 29, 2026

COPD

scRNA-seq · early-stage candidate

Spec Paper

Gastrointestinal & Hepatic

3 patents

P37 · 64/020,738 · Mar 29, 2026

MASH / Liver Fibrosis

scRNA-seq · early-stage candidate

Spec Paper

P48 · 64/029,386 · Apr 4, 2026

Eosinophilic Esophagitis

scRNA-seq · early-stage candidate

Spec Paper

P50 · 64/029,522 · Apr 4, 2026

Gastric Premalignant Lesions

scRNA-seq · early-stage candidate

Spec Paper

Metabolic & Endocrine

3 patents

P31 · 64/019,209 · Mar 27, 2026

WAT Browning (Obesity)

scRNA-seq · early-stage candidate

Spec Paper

P33 · 64/019,739 · Mar 27, 2026

Type 1 Diabetes

scRNA-seq · early-stage candidate

Spec Paper

P40 · 64/022,596 · Mar 31, 2026

Type 2 Diabetes / Pancreatic Islets

scRNA-seq · early-stage candidate

Spec Paper

Oncology

1 patent

P32 · 64/019,507 · Mar 27, 2026

Glioblastoma (GBM)

scRNA-seq · early-stage candidate

Spec Paper

Renal

1 patent

P46 · 64/027,911 · Apr 3, 2026

Chronic Kidney Disease

scRNA-seq · early-stage candidate

Spec Paper

Reproductive

1 patent

P47 · 64/029,152 · Apr 3, 2026

Endometriosis

scRNA-seq · early-stage candidate

Spec Paper

Cardiovascular

1 patent

P42 · 64/023,736 · Mar 31, 2026

Heart Failure / DCM

scRNA-seq · early-stage candidate

Spec Paper

Systemic & Multi-Organ

3 patents

P36 · 64/020,635 · Mar 29, 2026

Long COVID / POTS

scRNA-seq · early-stage candidate

Spec Paper

P45 · 64/026,746 · Apr 2, 2026

Inflammaging

scRNA-seq · early-stage candidate

Spec Paper

P49 · 64/029,481 · Apr 4, 2026

Sarcoidosis

scRNA-seq · early-stage candidate

Spec Paper

AI, Platform & Non-Biomedical

7 patents

P02 · 63/990,970 · Feb 25, 2026

Audit of Intent (AI Safety)

AI methodology

Spec

P03 · 63/999,401 · Mar 7, 2026

Printed Refolding

Molecular folding

Spec

P04 · 63/999,671 · Mar 8, 2026

MFOL

Molecular folding

Spec Paper

P05 · 64/000,777 · Mar 9, 2026

Olive Oil Antioxidant Triplet

Nutraceutical

Spec Paper

P06 · 64/005,354 · Mar 13, 2026

Drone Ball

Consumer product

Spec

P15 · 64/012,284 · Mar 20, 2026

Distributed Causal Memory

AI architecture

Spec Paper

P21 · 64/013,074 · Mar 22, 2026

Gut-targeted GABA-A PAM

Therapeutic design

Spec Paper